This story was reported by FairWarning, a nonprofit news organization based in Los Angeles that focuses on public health, safety and environmental issues.More than 200 scientists and public health advocates are urging regulators to take a closer look at the potential dangers of antimicrobial chemicals including triclosan, an additive that has been banned from hand soaps but remains an active ingredient in products ranging from building materials to Colgate\u2019s Total toothpaste.The call for better labeling and safety evaluation of the widely used substances comes in a paper published today in the journal Environmental Health Perspectives. The scientists say they worry that such chemicals, described as endocrine disruptors, have been linked to reproductive and developmental problems in animals and might harm human fetuses and newborns.\u201cWe therefore call on the international community to limit the production and use of triclosan and triclocarban and to question the use of other anti-microbials,\u201d say the scientists in what they are calling \u201cThe Florence Statement,\u201d first introduced at a 2016 conference in Italy.After decades of consideration, the U.S. Food and Drug Administration issued a final rule last year halting the sale of body washes and liquid and bar soaps containing triclosan or 18 similar ingredients. The FDA determined that scientific evidence did not show that these products were any better at preventing illness than old-fashioned soap and water. At the same time, the agency said, there were questions about possible long-term harm from the antimicrobial chemicals.The soap sales ban takes effect in September. Yet the chemicals, which attack mold and other microbes but linger in the human body and environment, are still used in more than 2,000 consumer and building products including toothpaste, detergents, clothing, toys, exercise mats, doorknobs and paints, the scientists say.Substitutes 'may be worse'\u201cEnvironmental and human exposures to triclosan and triclocarban are widespread, affecting pregnant women, developing fetuses, and breast-feeding babies,\u201d said Rolf Halden, a professor of engineering at Arizona State University and co-author of the new paper. \u201cWe must develop better alternatives and prevent unneeded exposures to antimicrobial chemicals.\u201dOne potential problem, however, is that some substitutes have yet to be fully tested and could raise concerns of their own. \u201cI was happy that the FDA finally acted to remove these chemicals from soaps,\u201d said Arlene Blum, executive director of the Green Science Policy Institute in Berkeley, Calif. \u201cBut I was dismayed to discover at my local drugstore that most products now contain substitutes that may be worse.\u201dColgate, whose Total toothpaste contains .3% triclosan aimed at combating plaque germs, declares on its website: \u201cWhile the FDA may be unconvinced by the support submitted by the soap companies, that\u2019s not the case with Colgate Total. \u2026 After an exhaustive review, the agency determined that Colgate Total provides a meaningful therapeutic benefit and is safe for consumers.\u201dThat safety claim, the company says, is based on a review in 2012 by an independent British research organization of 30 studies assessing the effects on oral health of triclosan in toothpaste. While their review focused on the toothpaste\u2019s impact on plaque, gingivitis, periodontitis and tooth decay, the authors also reported finding no serious safety concerns in studies of up to three years long.The scientists, in their statement today, recommend that triclosan and similar antimicrobials be avoided except \u201cwhere they provide an evidence-based health benefit\u201d and adequate evidence of safety is available. An example, they said in the statement, would be toothpaste prescribed by doctors to treat gum disease.FDA continues to evaluateThe ban on antimicrobial soaps came more than 40 years after the FDA first announced in 1974 that it would evaluate the active ingredients in over-the-counter antimicrobial drug products.In a statement to FairWarning, the FDA says it is continuing \u2018to evaluate the safety and effectiveness of antiseptic ingredients in other products, like consumer antiseptic rubs and health care antiseptics.\u201dThe agency is also evaluating hand sanitizers that are used without water, and has deferred action on three other substances \u2013 benzalkonium chloride, benzethonium chloride and chloroxylenol \u2013 to allow for new safety and effectiveness data.The American Cleaning Institute, a trade group for cleaning products makers that had defended the use of triclosan, said in an email to FairWarning that the other three ingredients also are safe and effective.Signers of the Florence Statement include scientists and health professionals from Sweden, Slovakia, Spain, Ireland, Iceland and other countries, and from U.S. institutions including Stanford, Johns Hopkins and state universities in California, North Carolina, Massachusetts and Arizona.